Weight-loss medications continue to grow in popularity as an anti-obesity tool but are some more effective than others?The question was explored in a new study published this month in The New England Journal of Medicine.Researchers compared the safety and efficacy of tirzepatide (brand name Zepbound) and semaglutide (brand name Wegovy) in a 72-week clinical trial.WEIGHT-LOSS MEDICATIONS MAY ALSO BENEFIT COMMON MEDICAL PROBLEM, STUDY FINDSThe randomized, controlled trial called SURMOUNT-5 included 751 people throughout the U.S. and Puerto Rico who had obesity but not type 2 diabetes."Doctors, insurance companies and patients are always asking, Which drug is more effective?" said Dr. Louis Aronne, director of the Comprehensive Weight Control Center and the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medicine, in the release. "This study allowed us to do a direct comparison.""The results are consistent with in fact, almost identical to what weve seen in trials in which these drugs were evaluated independently," added Aronne, who was a principal investigator in the trial.The study found that tirzepatide achieved greater weight loss, with participants shedding about 50 pounds (20.2% of their body weight).The group taking semaglutide lost an average of 33 pounds or 13.7% of their baseline weight, according to a press release summarizing the study outcome.Overall, 32% of the people taking tirzepatide lost at least 25% of their body weight; semaglutide users lost around 16%.WEIGHT LOSS, DIABETES DRUGS CAN CAUSE MOOD CHANGES: WHAT TO KNOW ABOUT BEHAVIORAL SIDE EFFECTSTirzepatide users also reported a "greater reduction in waist circumference" than those on semaglutide.The likely reason for tirzepatides greater effectiveness is that it uses a "dual mechanism of action," according to Aronne."Whereas semaglutide works by activating receptors for a hormone called glucagon-like peptide 1, or GLP-1, tirzepatide mimics not only GLP-1, but also an additional hormone, glucose-dependent insulinotropic peptide (GIP)," the release stated."Together, these actions reduce hunger, lower blood-glucose levels and affect fat cell metabolism."WEIGHT-LOSS DRUGS IMPACT ON CANCER RISK REVEALED IN NEW STUDYAdditional trials are actively exploring whether tirzepatide also reduces the risk of heart attack and stroke, a benefit that has been linked to semaglutide.The study, which was led by an investigator at Weill Cornell Medicine and NewYork-Presbyterian, was also conducted with the University of Texas McGovern Medical School, the David Geffen School of Medicine at the University of California, Los Angeles, the University College Dublin and Eli Lilly (maker of Zepbound).The participants all received guidance regarding nutrition and exercise.The reported side effects were very similar for the two drugs, with 44% experiencing nausea and 25% having abdominal pain.WEIGHT-LOSS DRUGS TO GET SURPRISING ENDORSEMENT FROM GLOBAL HEALTH GIANTDr. Ada Londono, MD, a board-certified obesity and internal medicine primary care physician with PlushCare a virtual health platform offering primary care, therapy and weight management services said she was not surprised by the study's findings."The results are consistent with prior trials, confirming tirzepatides advantage over semaglutides single GLP-1 action," Londono, who is based in New York City, told Fox News Digital.Beyond weight loss, semaglutide has also shown potential benefits for cardiovascular health, sleep apnea and kidney disease, she noted."These findings highlight the need for continued research to understand tirzepatides broader health impacts," she said. "Its encouraging to see ongoing studies exploring the full potential of GLP-1 medications beyond weight management."Londono pointed out that these treatments can come with side effects.SEMAGLUTIDE FOUND TO HAVE SHOCKING BENEFIT FOR LIVER DISEASE PATIENTS IN NEW STUDY"Most people on these medications only report mild symptoms, but some have experienced more serious reactions, such as pancreatitis," she told Fox News Digital."This underscores the importance of reviewing your medical history and discussing any concerns with your healthcare provider."The study did have some limitations chiefly that it was not a blinded analysis and participants knew which medication they were receiving. This could introduce some level of bias, the researchers acknowledged.Londono pointed out that while the studys findings are "promising," it was funded by Eli Lilly, the manufacturer of Zepbound."This may raise questions about potential conflicts of interest," she said. "Additionally, the open-label design and 72-week duration may limit objectivity and long-term insight."While the study primarily looked at the impact of the medications, experts agreed that there are other factors that play a role in successful weight management."Weight loss is biological, but its also emotional, and whole-person support can make the difference between short-term results and sustainable health," Dr. Rekha Kumar, chief medical officer at the weight care program Found and a practicing endocrinologist in New York City, told Fox News Digital.Kumar emphasized the importance of working with a physician to choose a weight-loss medication that matches the patients personal goals and health status."For example, if a patient has fatty liver, we will choose the GLP-1 that is proven to work best for liver disease," she said.Looking ahead, the researchers plan to investigate new versions of weight-loss drugs, including retatrutide, which mimics the hormones GLP-1, GIP and glucagon, according to the release.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER"Even though drugs like tirzepatide and semaglutide work really well, better than anything we have ever seen, we still have people who don't respond to them," said Aronne."So, moving forward, we want to keep trying to do better."A spokesperson from Novo Nordisk, the company that makes Wegovy (semaglutide), sent the below statement to Fox News Digital."Across the respective clinical trial programs and in SURMOUNT-5, both Wegovy and Zepbound have demonstrated clinically significant weight reduction. It is important to recognize that the comprehensive management of obesity goes beyond weight reduction alone."For more Health articles, visitwww.foxnews.com/healthThe spokesperson also pointed out that in a previous trial, adults with obesity or overweight who took Wegovy along with diet and exercise had lost an average of 15.2% of their weight (~35 pounds) at the two-year mark, compared with 2.6% (~6 pounds) for patients taking a placebo.

'OutKick' founder Clay Travis and political strategist Lucy Caldwell react to President Donald Trump's move to ban foreign students from attending Harvard.

Fox News contributor and U.S. Marine veteran Joey Johnson explains why military recruitment is off to a strong start and teases his new book 'Behind the Badge' on 'One Nation.'

Fox News host Brian Kilmeade reflects on the true meaning of Memorial Day on One Nation.

'OutKick' founder Clay Travis and political strategist Lucy Caldwell react to President Donald Trump's move to ban foreign students from attending Harvard.

Fox News contributor and U.S. Marine veteran Joey Johnson explains why military recruitment is off to a strong start and teases his new book 'Behind the Badge' on 'One Nation.'

Fox News host Brian Kilmeade reflects on the true meaning of Memorial Day on One Nation.

President Donald Trump last week announced he would normalize U.S. relations with Syria by lifting decades-old sanctions, and he became the first American president to meet with the leader of the Middle Eastern nation in 25 years a move that some have seen as an indirect hit on Iran.The news was a surprising shift from Trumps prior position in which he said in a December post that "Syria is a mess, but is not ourfriend, & THE UNITED STATES SHOULD HAVE NOTHING TO DO WITH IT."Trumps change of posture is a gamble that could see serious gains regarding regional stability and securing U.S. interests by deterring Iranian influence, explained Behnam Ben Taleblu, Iran expert and senior fellow with the Foundation for Defense of Democracies.US AMBASSADOR BARRACK NAMED SPECIAL ENVOY TO SYRIA AMID SANCTIONS RELIEF PLAN"This is what I call a high-risk, high-reward gamble, but one that, if achieved successfully, can actually prevent Syria from being a launching pad for more Iranian malign activity," Ben Taleblu told Fox News Digital. "But if it fails, . . . Washington would have ended up empowering a jihadist government in Damascus [that] does not have full control over its own territory."The December collapse of the Bashar al-Assad regime following the takeover by Hay'at Tahrir al-Sham (HTS), a former al-Qaeda affiliate, not only signified an end to a decades-long oppressive regime, it also effectively dismantled years of Iranian investment in a major setback to its regional influence. Trump emphasized that this sanctions relief, which he argued will give the country a chance to recover and was soon followed by an EU order to lift sanctions, is a move to encourage Syria to normalize diplomatic ties with Israel.But Syrian President Ahmed al-Sharaa, who is also the leader of HTS, which is still a designated terrorist group under the U.S. and the UN, has not officially agreed to pursue diplomatic ties with Jerusalem a push several Middle Eastern nations have flatly rejected amid its aggressive military operations in the Gaza Strip.Trump also emphasized that the new Syrian government needs to suppress the rise of Islamic extremist groups, which Ben Taleblu pointed out is going to be one of the nations chief vulnerabilities as it looks to completely re-establish itself in the world order as trade, business and diplomacy have been reopened to Damascus.IRAN'S KHAMENEI LAUNCHES BLISTERING ATTACK ON TRUMP AFTER MIDDLE EAST VISIT"Tehran traditionally responds to these sorts of things with patience. The Islamic Republic has an ideological view of the way the region should be oriented, and has put time, money, resources, blood and treasure towards that," Ben Taleblu said.The Iran-expert explained that Tehran is waiting for the U.S. and Israel to loosen its pressure on the regime and its proxies, "and for Washington and Jerusalem to make mistakes in the region as they try to push towards bigger-picture things like flipping Syria or regional peace and stability.""And it is there that in the interim, while Washington focuses up on building up states that Tehran will focus on building up proxies and partners," he added.Syria is not a united nation as conflict persists across the country between varying minority groups, former regime loyalists and terrorist organizations like ISIS.Secretary of State Macro Rubio also warned lawmakers on Tuesday that Syria could be just "weeks" away from a"potential collapse and a full-scale civil war of epic proportions."These fractures pose a significant vulnerability for the new Syrian government."Whenever there is a downtrodden or dispossessed person in a war zone or in a conflict zone, that is Tehran's angle of entry back into a conflict," Ben Taleblu said. "This has been Irans strategy, sitting and waiting and looking to exploit opportunities across the entire northern tier of the Middle East, from Iraq to Syria to Lebanon."Exploiting disarray is a specialty of the Islamic Republic," he warned.The expert explained that if the Trump administration wants to ensure that Iran is unable to exploit vulnerable populations in Syria, then it will need to press Damascus to address the sweeping concerns facing various groups across the country.Though the president, and his constituents, notoriously opposed nation-building, which could spell trouble for the long-term security of Syria as it sits in Irans shadow."Tehran is going to be playing the long game. It's going to be running the clock when it comes to American and Israeli patience for what the future regional order could look like," Ben Taleblu warned.

President Donald Trump last week announced he would normalize U.S. relations with Syria by lifting decades-old sanctions, and he became the first American president to meet with the leader of the Middle Eastern nation in 25 years a move that some have seen as an indirect hit on Iran.The news was a surprising shift from Trumps prior position in which he said in a December post that "Syria is a mess, but is not ourfriend, & THE UNITED STATES SHOULD HAVE NOTHING TO DO WITH IT."Trumps change of posture is a gamble that could see serious gains regarding regional stability and securing U.S. interests by deterring Iranian influence, explained Behnam Ben Taleblu, Iran expert and senior fellow with the Foundation for Defense of Democracies.US AMBASSADOR BARRACK NAMED SPECIAL ENVOY TO SYRIA AMID SANCTIONS RELIEF PLAN"This is what I call a high-risk, high-reward gamble, but one that, if achieved successfully, can actually prevent Syria from being a launching pad for more Iranian malign activity," Ben Taleblu told Fox News Digital. "But if it fails, . . . Washington would have ended up empowering a jihadist government in Damascus [that] does not have full control over its own territory."The December collapse of the Bashar al-Assad regime following the takeover by Hay'at Tahrir al-Sham (HTS), a former al-Qaeda affiliate, not only signified an end to a decades-long oppressive regime, it also effectively dismantled years of Iranian investment in a major setback to its regional influence. Trump emphasized that this sanctions relief, which he argued will give the country a chance to recover and was soon followed by an EU order to lift sanctions, is a move to encourage Syria to normalize diplomatic ties with Israel.But Syrian President Ahmed al-Sharaa, who is also the leader of HTS, which is still a designated terrorist group under the U.S. and the UN, has not officially agreed to pursue diplomatic ties with Jerusalem a push several Middle Eastern nations have flatly rejected amid its aggressive military operations in the Gaza Strip.Trump also emphasized that the new Syrian government needs to suppress the rise of Islamic extremist groups, which Ben Taleblu pointed out is going to be one of the nations chief vulnerabilities as it looks to completely re-establish itself in the world order as trade, business and diplomacy have been reopened to Damascus.IRAN'S KHAMENEI LAUNCHES BLISTERING ATTACK ON TRUMP AFTER MIDDLE EAST VISIT"Tehran traditionally responds to these sorts of things with patience. The Islamic Republic has an ideological view of the way the region should be oriented, and has put time, money, resources, blood and treasure towards that," Ben Taleblu said.The Iran-expert explained that Tehran is waiting for the U.S. and Israel to loosen its pressure on the regime and its proxies, "and for Washington and Jerusalem to make mistakes in the region as they try to push towards bigger-picture things like flipping Syria or regional peace and stability.""And it is there that in the interim, while Washington focuses up on building up states that Tehran will focus on building up proxies and partners," he added.Syria is not a united nation as conflict persists across the country between varying minority groups, former regime loyalists and terrorist organizations like ISIS.Secretary of State Macro Rubio also warned lawmakers on Tuesday that Syria could be just "weeks" away from a"potential collapse and a full-scale civil war of epic proportions."These fractures pose a significant vulnerability for the new Syrian government."Whenever there is a downtrodden or dispossessed person in a war zone or in a conflict zone, that is Tehran's angle of entry back into a conflict," Ben Taleblu said. "This has been Irans strategy, sitting and waiting and looking to exploit opportunities across the entire northern tier of the Middle East, from Iraq to Syria to Lebanon."Exploiting disarray is a specialty of the Islamic Republic," he warned.The expert explained that if the Trump administration wants to ensure that Iran is unable to exploit vulnerable populations in Syria, then it will need to press Damascus to address the sweeping concerns facing various groups across the country.Though the president, and his constituents, notoriously opposed nation-building, which could spell trouble for the long-term security of Syria as it sits in Irans shadow."Tehran is going to be playing the long game. It's going to be running the clock when it comes to American and Israeli patience for what the future regional order could look like," Ben Taleblu warned.

Autonomous delivery robots are already starting to change the way goods move around cities and warehouses, but most still need humans to load and unload their cargo. That's where LEVA comes in. Developed by engineers and designers from ETH Zurich and other Swiss universities, LEVA is a robot that can not only navigate tricky environments but also lift and carry heavy boxes all on its own, making deliveries smoother and more efficient.Join the FREE "CyberGuy Report": Get my expert tech tips, critical security alerts and exclusive deals, plus instant access to myfree "Ultimate Scam Survival Guide" when you sign up!Most delivery robots either roll on wheels or walk on legs, but LEVA combines both. It has four legs, and each leg ends with a motorized, steerable wheel. This means on smooth surfaces like sidewalks, LEVA can roll quickly and efficiently, almost like a little car. When it encounters stairs, curbs or rough ground, it locks its wheels and walks or climbs like a four-legged animal. This unique design lets LEVA handle both flat urban streets and uneven terrain with ease.RICE-SIZED ROBOT COULD MAKE BRAIN SURGERY SAFER AND LESS INVASIVELEVA uses a mix of GPS, lidar sensors and five cameras placed around its body to understand its surroundings. These tools help it navigate city streets or indoor hallways while avoiding obstacles. One camera even looks downward to help LEVA line itself up perfectly when it's time to pick up or drop off cargo.DRIVERLESS BIG-RIG ROBOTRUCKS ARE NOW ON THE ROAD IN THIS STATEWhat really sets LEVA apart is its ability to load and unload cargo boxes without any human help. It spots a standard cargo box, moves right over it, lowers itself by bending its legs and then locks onto the box using powered hooks underneath its body. After securing the box, LEVA lifts itself back up and carries the load to its destination. It can handle boxes weighing up to 187 pounds, which is pretty impressive for a robot of its size.CHINESE HUMANOID ROBOT WITH EAGLE EYE VISION AND POWERFUL AILEVA is about 4 feet long and 2.5 feet wide, with an adjustable height between 2 and 3 feet. It weighs around 187 pounds and can carry the same amount of cargo. Thanks to its wheels and legs, it can move smoothly on flat surfaces, climb stairs and handle rough terrain. Its sensors and cameras give it a sharp sense of where it is and what's around it.HOW TO REMOVE YOUR PERSONAL INFO FROM PEOPLE-SEARCH SITESLEVA's flexibility makes it useful in many places. It could deliver packages right to your doorstep, even if you live in a building with stairs. Farmers might use it to move supplies across fields. On construction sites, it could carry tools and materials over uneven ground. It might even assist in emergency situations by bringing supplies through rubble or rough terrain.For folks like us, LEVA could mean faster, more reliable deliveries, especially in tricky urban areas where stairs and curbs often slow things down. For businesses, it means cutting down on the need for manual labor to load and unload heavy items, which can reduce injuries and lower costs.It also means deliveries and material handling could happen around the clock without breaks, boosting efficiency. In industries like farming, construction and emergency response, LEVA's ability to get through tough terrain while carrying heavy loads could make a big difference in how quickly and safely supplies get where they need to go.HOW SECURE IS MY PASSWORD? USE THIS TEST TO FIND OUTThe first LEVA prototype has shown it can do a lot, but there's still work to be done. The team is improving its energy use, making it better at climbing stairs, and enhancing its ability to operate fully on its own. The goal is to have LEVA become a reliable part of automated delivery systems that work smoothly in real-world settings.SUBSCRIBE TO KURTS YOUTUBE CHANNEL FOR QUICK VIDEO TIPS ON HOW TO WORK ALL OF YOUR TECH DEVICESLEVA blends the best of wheels and legs with the unique ability to load and unload itself. This makes it a promising tool for industries that need robots to be flexible, strong and smart. As LEVA continues to develop, it could change the way deliveries and material transport happen, making them faster, safer and more efficient for everyone.How much would you trust a robot to handle your valuable or fragile shipments without human supervision? Let us know by writing us atCyberguy.com/Contact.For more of my tech tips and security alerts, subscribe to my free CyberGuy Report Newsletter by heading toCyberguy.com/Newsletter.Ask Kurt a question or let us know what stories you'd like us to cover.Follow Kurt on his social channels:Answers to the most-asked CyberGuy questions:New from Kurt:Copyright 2025 CyberGuy.com.All rights reserved.