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WWW.FOXNEWS.COMCancer drug could double as autism therapy, and is poised for FDA approvalDuring a Monday press conference about various autism topics, federal health officials noted the potential for an existing cancer drug to double as therapy for the neurodevelopmental condition.FDA Commissioner Marty Makary, National Institutes of Health (NIH) Director Jay Bhattacharya, and Centers for Medicare and Medicaid Services Administrator Mehmet Oz discussed research suggesting that leucovorin, a prescription vitamin used to treat cancer and anemia, is effective in off-label use for children with autism.The FDA plans to approve prescription leucovorin as a "potential treatment for speech-related deficits associated with ASD," according to a press release from HHS. The agency will update the label for leucovorin to indicate treatment for cerebral folate deficiency, which has been associated with autism.PRESIDENT TRUMP TIES AUTISM TO WIDELY USED OVER-THE-COUNTER DRUGAfter the label update, state Medicaid programs will be able to cover the drug for autism treatment, the release stated.The NIH will also launch new research initiatives into leucovorin's safety and effectiveness.Studies have shown that leucovorin could help some non-verbal children gain the ability to speak.Leucovorin functions similarly to folic acid, helping to restore folate levels in patients who may have difficulty absorbing or using it, according to Katy Dubinsky, a New York pharmacist and the CEO and co-founder of Vitalize, a private supplement company.TRUMP TO REVEAL MEDICAL FINDING HE CALLS ANSWER TO AUTISM IN MAJOR ANNOUNCEMENT"Leucovorin is FDA-approved to reduce the toxic effects of high-dose methotrexate in cancer treatment and to prevent or treat certain types of anemia caused by folate deficiency," Dubinsky previously told Fox News Digital.While leucovorin isnt yet prescribed for the treatment of autism, some families have found that its off-label use has led to significant improvements in autistic childrens communication skills, experts say.Richard E. Frye, M.D., Ph.D., a behavioral child neurologist in Arizona, has studied the drug in his research of experimental treatments for children with autism spectrum disorder."Leucovorin is a special form of vitamin B9 that is water-soluble and does not build up in your body," he previously told Fox News Digital.RISING AUTISM RATES NOW AFFECT 3% OF CHILDREN, SAYS CDC REPORT"Folates have been found to be safe long-term for many years and that is why we supplement our food with folate."Leucovorin's main benefit for children with autism is improvement in language, Frye said, but other advantages may include enhanced social function, reduced repetitive behaviors and stronger attention skills."We do find that leucovorin helps a substantial number of children with autism," he said. "Language is one of the most obvious things, so that is what we measured in our clinical trial."Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News' senior medical analyst, also spoke to Fox News Digital about why the drug may have this positive impact."Central folate deficiency is a lack of folate in the brain, which can interfere with neurological function," he said earlier this year. "A high percentage of children with autism spectrum disorder have been found to have antibodies against folic receptor alpha in the brain."Leucovorin is converted to folate in the brain by a different pathway, Siegel said."Small studies are showing that it improves neurological function and communication skills in kids with ASD, but larger studies need to be done."The fact that leucovorin has already been used long-term helps to reduce the associated risk, doctors say."One of the advantages of using leucovorin is that it's been used for decades to protect the body from the effects of chemotherapy, so we know what dose to use and any side effects it may produce," Frye told Fox News Digital.However, some children do become "extremely hyperactive," do not respond to leucovorin and need alternative treatments, the doctor noted.Its important for families to work with a medical professional when exploring the use of leucovorin for autism, he advised."Leucovorin is given at much higher doses than regular vitamins, so its very important to work with a doctor knowledgeable in how to prescribe it," Frye said.While leucovorin is available at pharmacies, Frye said some children need a compounded form because they are sensitive to some of the additives in commercial products."Our goal is to get leucovorin approved by the FDA for autism so it can be widely prescribed to children as one of the first treatments once they are diagnosed," he previously said.Dubinsky agreed physicians may prescribe the "widely used and well-tolerated drug" for autism treatment based on their "clinical judgment and emerging evidence" but also stressed the importance of clinical trials."FDA approval would provide stronger medical backing, making it a recognized treatment rather than just an off-label option," she told Fox News Digital.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER"This could lead to insurance coverage, standardized dosing guidelines and broader acceptance in the medical community."Siegel added that leucovorin is a "safe drug" and should be considered for large-scale use based on the findings of recent research.Frye said there is "no magic bullet" for autism, with many children benefiting from a combination of multiple treatments."It is unlikely that leucovorin will be used alone it must be used with behavioral and speech therapy," he said. "We believe that leucovorin can improve outcomes for these therapies."Andy Shih, Ph.D., chief science officer of Autism Speaks in New York, noted that every childs experience with autism is unique."There is little evidence to suggest that the benefits observed [in individual cases] can be generalized to the broader autistic community," he previously told Fox News Digital.For more Health articles, visitwww.foxnews.com/health"While some small studies have explored leucovorin as a potential treatment for people with autism, larger controlled clinical trials are needed to determine its efficacy and safety. We urge families to consult with their doctors before considering off-label treatments."Dubinsky added that if larger studies confirm leucovorins effectiveness, it could become a more accessible treatment for children with autism who may benefit from it.0 Comments 0 Shares 56 Views 0 Reviews
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WWW.FOXNEWS.COMMaher and anti-Trump director Rob Reiner clash over whether right and left should still talk with each otherOn Mondays episode of his "Club Random" podcast, comedian Bill Maher sparred with Hollywood director Rob Reiner over whether the right and left in America should keep talking to each other.Maher insisted that both sides should continue talking despite the heightened political tensions in the country inflamed in recent weeks by the assassination of Charlie Kirk while the Hollywood liberal said there might be exceptions if people cant agree on basic facts. Maher disagreed, calling Reiners point a slippery slope."Before you have the exchange, you have to agree on certain facts," Reiner said.Maher replied, "No, you dont. You cant. Once you start down that road you just have to talk to people."CHARLIE KIRK ALLY DEFENDS JIMMY KIMMEL SUSPENSION OVER 'VILE LIE' AMID FIRST AMENDMENT CRITICISMReiner, an outspoken critic of President Donald Trump, opened the discussion by saying conservatives and liberals today are less willing to sit down and hash out issues than in previous eras.Maher agreed and criticized Democrats for refusing bipartisan cooperation at a time when Republicans hold more political power."This would make some sense for the Democrats if they had any power," he said. "But the idea of we dont talk to you when we dont even have the power? Of course, you have to talk to people."LIBERALS RAGE AS ABC PULLS JIMMY KIMMEL OFF AIR FOLLOWING CHARLIE KIRK ASSASSIN COMMENTSReiner partially agreed, though he maintained that there has to be some agreement between both sides before dialogue can start. Maher rejected that idea, though Reiner pushed back."No, no, you talk to people. But if somebody says two plus two is four and the other guy says, No, its not, how do you begin the discussion?" he asked."Because, Rob, that's a slippery slope," Maher replied.Elsewhere, the host told the filmmaker, "If you start down that road of I cant talk to you if you believe this crazy thing because maybe you just can't."CLICK HERE FOR MORE COVERAGE OF MEDIA AND CULTUREReiner needed more convincing."Lets say youre having a conversation with that person," he said, using the example of someone who denies the moon landing. "So what do you say after that?" he asked.Maher offered his solution."Same thing you would do in a marriage," he said.He continued: "Its very like a relationship. And no, I have not been married, but I have been in long-term serious relationships. And I know there are moments where the person is believing something and you just every fiber of your being wants to be like, I got to get this person to not see it that way, cause I just think its f------ nuts.""And if you want that relationship to last, youre gonna have to learn the three little words that are most important to any relationship, and theyre not I love you. Theyre, Let it go," Maher added.0 Comments 0 Shares 57 Views 0 Reviews
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WWW.FOXNEWS.COMCowboys' CeeDee Lamb could miss 3-4 weeks after suffering high ankle sprain in loss to Bears: reportThe Dallas Cowboys are expected to be without star wide receiver CeeDee Lamb for several weeks.Lamb, quarterback Dak Prescotts top target, suffered a high ankle sprain in Sundays loss to the Chicago Bears. The injury could sideline him three to four weeks, according to ESPN.Stephen Jones, the Cowboys executive vice president and son of owner Jerry Jones, told 105.3 The Fan in Dallas that the team still needs to evaluate Lambs condition but admitted it doesnt look promising."I think weve got to evaluate the full thing and see how hes moving around as the day goes," Jones said. "Certainly, hes got the high ankle sprain, and every one of those are different. Wed love to have him back for Green Bay, but at the same time, we also got to understand the injury is what it is, and well play it out."CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COMDallas faces the Packers on Sunday in a highly anticipated matchup, given the blockbuster Micah Parsons trade between the two teams before the 2025 season.JERRY JONES ASSESSES COWBOYS DEFENSE WITHOUT MICAH PARSONS IN LOSS TO EAGLESLamb said the injury is "absolutely" something he believes he could play through. He was hurt in the first quarter when Bears linebacker Noah Sewell fell across both of his legs during a rushing attempt. Replay showed Lambs ankle twist awkwardly before he walked gingerly off the field and into the medical tent.He briefly returned to run one route but exited for good. After the game, he was seen wearing a walking boot. An MRI on Monday confirmed the sprain.The loss of Lamb, even temporarily, is significant for the Cowboys. He opened the year with back-to-back 100-yard receiving games before leaving Sundays contest.Lamb has dealt with injuries before, missing just three games in his Dallas career. He was sidelined by a concussion in 2021 and a shoulder injury in 2024 that cost him two games."It changes quite a bit," Jones said of the offense without Lamb. "When youre able to have both out there, its a huge plus. Certainly, Pickens can do a great job for us in the role."The Cowboys will rely on George Pickens, who showed visible frustration during the Bears loss, as well as tight end Jake Ferguson and receivers KaVontae Turpin and Jalen Tolbert to help fill the void.Follow Fox News Digitalssports coverage on X, and subscribe tothe Fox News Sports Huddle newsletter.0 Comments 0 Shares 70 Views 0 Reviews
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WWW.FOXNEWS.COMSpider-Man star Tom Holland suffers head injury during stunt gone wrongTom Holland suffered a mild concussion on the set of "Spider-Man: Brand New Day" after a stunt went wrong.According to Deadline, filming was suspended temporarily Friday after Holland was taken to the hospital. The actor was reportedly treated and released, not admitted.A source close to production told the outlet that Holland will take a break "out of precaution," but is expected to return to filming in a few days.Holland does not appear to have been seriously injured. According to The Sun, the actor attended a charity event with his co-star and fiance Zendaya and his father over the weekend. However, he reportedly left early because he wasn't feeling well.TOM CRUISE NEARLY BROKE HIS BACK PERFORMING BRUTAL MISSION: IMPOSSIBLE STUNTA representative for Holland did not immediately respond to Fox News Digital's request for comment.This isn't the first on-set injury to make headlines recently.Earlier this year, Charlize Theron revealed that while filming her latest action-packed project, "Apex," she sustained a painful injury after performing some of her own stunts without protective gear.LIKE WHAT YOURE READING? CLICK HERE FOR MORE ENTERTAINMENT NEWS"Our crew delivered a really impressive movie, and yours truly did some stunts and action without a harness, sometimes," Theron said at Netflixs 2025 upfront presentation in May, according to Entertainment Weekly. "Don't tell Netflix.""It's actually a miracle that I'm here today," she noted."'Apex' only wrapped like a week ago, so I'm fresh off the mountain. I still have some Australian dirt under this pretty manicure, and my cute boot is hiding a fractured toe ... I can go on and on and on, but I won't."Despite the physical toll, Theron, 49, remained in good spirits as she recovered."I can honestly say that shooting Apex was one of the most incredible experiences of my life," she said.CLICK HERE TO SIGN UP FOR THE ENTERTAINMENT NEWSLETTERTom Cruise also suffered a serious injury while performing a stunt on the set of "Mission: Impossible The Final Reckoning."In bonus content from the digital release of the film, Cruise and director Christopher McQuarrie broke down one of the movies most harrowing sequences: a high-flying biplane battle between Cruise's character, Ethan Hunt, and Gabriel, portrayed by Esai Morales."Oh, this almost broke my back," Cruise, whose character was leaping from one plane to another, revealed in the commentary, per Entertainment Weekly."Youre talking about a lot of pain here," McQuarrie chimed in."Now watch this, the thing we havent talked about, holding on to this belt," McQuarrie described, while Cruise said, "Oh God, that was brutal."The director went on to explain, "This separated the joints in Tom's fingers from the force, so by the time we finished this sequence, your hands were absolutely swollen oh my God, it was so painful to watch."Fox News Digital's Stephanie Giang-Paunon contributed to this report.0 Comments 0 Shares 60 Views 0 Reviews
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